2002-2006,中国科学技术大学化学与材料科学学院,高分子化学学士
2006-2011,中国科学技术大学化学与材料科学学院,高分子科学博士
博士学位论文:可降解高分子纳米颗粒及其作为药物输送载体的研究
毕业后去向:美国埃默里大学,博士后
现联系方式: djzhi@mail.ustc.edu.cn; djzhi83@gmail.com
所获奖励:2011年通用电器基金会科技创新一等奖、2011年远东企业奖、2011年博士研究生学术新人奖、2011年中国科学院“院长奖”、2010年中国科学院朱李月华优秀博士生奖、2009年东港奖学金、2006年航天信息奖助学金
研究生期间发表论著:
1. Yang Li, Feng Wang, Tian-Meng Sun, Jin-Zhi Du, Xian-Zhu Yang*, Jun Wang*,Intracellular Responsive Polymer Nanoparticles Modulated by the Surface for Enhanced Drug Delivery, Science China Chemistry, 2014, 57, 579-585
2. Hong-Jun Li, Hong-Xia Wang, Chun-Yang Sun, Jin-Zhi Du*, Jun Wang*, Shell-detachable Nanoparticles Based on A Light-Responsive Amphiphile for Enhanced siRNA Delivery, RSC Advances, 2014, 4, 1961-1964
3. Tian-Meng Sun, Yu-Cai Wang, Feng Wang, Jin-Zhi Du, Cheng-Qiong Mao, Chun-Yang Sun, Rui-Zhi Tang, Yang Liu, Jing Zhu, Yan-Hua Zhu, Xian-Zhu Yang, Jun Wang*, Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds, Biomaterials, 2014, 35, 836-845
4. Jin-Zhi Du, Cheng-Qiong Mao, You-Yong Yuan, Xian-Zhu Yang, Jun Wang*, Tumor Extracellular Acidity-Activated Nanoparticles as Drug Delivery Systems for Enhanced Cancer Therapy, Biotechnology Advances, 2013, in press (invited review)
5. Chun-Yang Sun, Shuang Dou, Jin-Zhi Du, Xian-Zhu Yang, Ya-Ping Li, Jun Wang*, Doxorubicin Conjugate of Poly(ethylene glycol)-block-Polyphosphoester for Cancer Therapy, Advanced Healthcare Materials, 2014, 3, 261-272
6. You-Yong Yuan, Chen-Qiong Mao, Xiao-Jiao Du, Jin-Zhi Du, Feng Wang, Jun Wang*, Surface Charge Switchable Nanoparticles based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor, Advanced Materials, 2012, 24, 5476-5480
7. You-Yong Yuan, Wen-Jing Song, Feng Wang, Jin-Zhi Du, Meng-Hua Xiong, Jun Wang*, Biocompatible and Functionalizable Polyphosphate Nanogels with A Branched Structure, Journal of Materials Chemistry, 2012, 22, 9322-9329
8. Xian-Zhu Yang, Jin-Zhi Du, Cheng-Qiong Mao, Hong-Yan Long, Jun Wang*, Sheddable Ternary Nanoparticles for Tumor Acidity-Targeted siRNA Delivery , ACS Nano, 2012, 6, 771-781 (most read articles, ACS Nano, Jan., 2012)
9. Jin-Zhi Du, Hong-Yan Long, You-Yong Yuan, Meng-Meng Song, Liang Chen, Hong Bi, Jun Wang*, Micelle-to-Vesicle Morphological Transition via Light-Induced Rapid Hydrophilic Arm Detachment from a Star Polymer, Chemical Communications, 2012, 48, 1257-1259
10. You-Yong Yuan, Jin-Zhi Du, Jun Wang*, Two Consecutive Click Reactions as a General Route to Functional Cyclic Polyesters,Chemical Communications, 2012, 48, 570-572
11. Jin-Zhi Du, Xiao-Jiao Du, Cheng-Qiong Mao, Jun Wang*, Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery, Journal of the American Chemical Society, 2011, 133, 17560-17563
12. Cheng-Qiong Mao, Jin-Zhi Du, Tian-Meng Sun, Yan-Dan Yao, Pei-Zhuo Zhang, Er-Wei Song, Jun Wang*, A BiodegradableAmphiphilic and Cationic Triblock Copolymer for the Delivery of siRNA Targeting the Acid Ceramidase Gene for Cancer Therapy,Biomaterials, 2011, 32, 3124-3133
13. Jin-Zhi Du, Ling-Yan Tang, You-Yong Yuan, Jun Wang*, Phosphoester modified poly(ethylenimine) as efficient and low cytotoxic genevectors, Science China Chemistry, 2011, 54, 351-358 (In honor of the 80th Birthday of Professors Shen Jia-Cong, Shen Zhi-Quan and Zhuo Ren-Xi)
14. 熊梦华,杜金志,王均*,聚磷酸酯纳米凝胶载药系统的研究进展,东南大学学报(医学版),2011,(1): 262-268
15. Tian-Meng Sun, Jin-Zhi Du, Yan-Dan Yao, Cheng-Qiong Mao, Shuang Dou, Song-Yin Huang, Pei-Zhuo Zhang, Kam W. Leong, Er-Wei Song*, Jun Wang*, Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression, ACS Nano, 2011, 5, 1483-1494
16. Yi-Quan Wu, I-Chien Liao, Scott J. Kennedy, Jin-Zhi Du, Jun Wang, Kam W. Leong, Robert L. Clark, Electrosprayed core-shell microspheres for protein delivery, Chemical Communications, 2010, 46, 4743-4
17. Xi-Qiu Liu, Jin-Zhi Du, Chu-Pei Zhang, Fang Zhao, Xian-Zhu Yang, Jun Wang*, Brush-shaped polycation with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery vector, International Journal of Pharmaceutics, 2010, 392, 118-126
18. Yu-Cai Wang, Juan Wu, Yang Li, Jin-Zhi Du, You-Yong Yuan, Jun Wang*, Engineering Nanoscopic Hydrogels via Photo-Crosslinking Salt-Induced Polymer Assembly for Targeted Drug Delivery, Chemical Communications, 2010, 46, 3520-3522
19. Jin-Zhi Du, Tian-Meng Sun, Wen-Jing Song, Juan Wu, Jun Wang*, A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery, Angewandte Chemie-International Edition, 2010, 49, 3621-3626
20. Wen-Jing Song, Jin-Zhi Du, Tian-Meng Sun, Pei-Zhuo Zhang, Jun Wang*, Gold Nanoparticles Capped with Polyethylenimine for Enhanced siRNA Delivery, Small, 2010, 6, 239-246
21. Yu-Cai Wang, You-Yong Yuan , Jin-Zhi Du, Xian-Zhu Yang, Jun Wang* , Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications, Macromolecular Bioscience, 2009, 9, 1154-1164 (Invited Feature Article)
22. Jin-Zhi Du, Ling-Yan Tang, Wen-Jing Song, Yue Shi, Jun Wang*, Evaluation of Polymeric Micelles from Brush Polymer with Poly(e-caprolactone)-b-Poly(ethylene glycol) Side Chains as Drug Carrier, Biomacromolecules, 2009, 10, 2169-2174
23. Ling-Yan Tang, Yu-Cai Wang,* Yang Li, Jin-Zhi Du, Jun Wang* , Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery, Bioconjugate Chemistry, 2009, 20, 1095-1099 (most-accessed article during April-June 2009)
24. 李来胜,童景,吴卷,杜金志,王均,用于输送siRNA的聚乙烯亚胺-聚乙二醇纳米凝胶,高分子学报,2009,(3), 257-263
25. You-Yong Yuan, Yu-Cai Wang, Jin-Zhi Du, Jun Wang* , Synthesis of Amphiphilic ABC 3-Miktoarm Star Terpolymer by Combination of Ring Opening Polymerization and “Click” Chemistry, Macromolecules, 2008, 41, 8620-8625
26. Wen-Jing Song, Jin-Zhi Du, Nan-Jun Liu, Shuan Dou, Jing Cheng, Jun Wang* , Functionalized Diblock Copolymer of Poly(ε-caprolactone) and Polyphosphoester Bearing Hydroxyl Pendent Groups: Synthesis, Characterization and Self-Assembly, Macromolecules, 2008, 41, 6935-6941
27. Tian-Meng Sun, Jin-Zhi Du (co-first author), Li-Feng Yan, Hai-Quan Mao, Jun Wang *, Self-Assembled Biodegradable Micellar Nanoparticles of Amphiphilic and Cationic Block Copolymer for siRNA Delivery, Biomaterials, 2008, 29, 4348-4355
28. Jin-Zhi Du, Tian-Meng Sun, Song-Qing Weng, Xue-Si Chen, Jun Wang*, Synthesis and Characterization of Photocrosslinked Hydrogel Based on Biodegradable Polyphosphoester and Poly(ethylene glycol) Copolymer, Biomacromolecules, 2007, 8, 3375-3381
29. Chun-Sheng Xiao, Yu-Cai Wang, Jin-Zhi Du, Xue-Si Chen, Jun Wang*, Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate, Macromolecules, 2006, 39, 6825-6831
30. Jin-Zhi Du, Dong-Ping Chen, Yu-Cai Wang, Chun-Sheng Xiao, Yi-Jie Lu, Jun Wang*, Guang-Zhao Zhang, Synthesis and Micellization of Amphiphilic Brush-Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester, Biomacromolecules, 2006, 7, 1898-1903
31. 王均、杜金志、孙春阳、都小姣、毛成琼,一种聚乙二醇单甲醚-聚磷酸酯两嵌段共聚物及其阿霉素键合药,中国发明专利,申请号:201110317008.7
32. 王均、毛成琼、杜金志、张佩琢,聚乙二醇单甲醚-聚己内酯-聚磷酸酯共聚物及其应用,中国发明专利,优先权申请:201010616377.1,申请日期,2010年12月31日
33. 王均、孙天盟、杜金志,一种药物载体及其应用,中国发明专利,申请号:200810246720.0
34. 王均、杜金志、窦双,聚乙二醇单甲醚-聚己内酯-聚乙烯亚胺三嵌段共聚物及其应用,中国发明专利,ZL 2008 1 0246719.8
35. 王均、杜金志、孙天盟,一种聚乙二醇单甲醚-聚己内酯-聚磷酸酯三嵌段共聚物及其制备的siRNA药物载体,中国发明专利,授权号:ZL 2008 1 0055945.8
36. Jun Wang*, You-Yong Yuan, Jin-Zhi Du, Polyphosphoesters: Controlled Ring-Opening Polymerization and Biological Applications,In: Matyjaszewski K and Möller M (eds.) Polymer Science: A Comprehensive Reference, Volume 4, pp. 719-747. Amsterdam:Elsevier BV.